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Best ED Pills For Men to Restore Love Life

Erectile Dysfunction (ED), or impotence, affects a large population of males in the United States and abroad. It is a common sexual problem in males all over the world. About 44% of men between 60 to 69 years old and up to 70% of men of 70 years and above have difficulty in achieving an erection. Elder men are the common victims of ED, but nowadays, many younger adults are also suffering from this type of sexual weakness.

ED is the persistent inability to achieve or sustain a penile erection for satisfactory sexual performance. ED can have a psychological impact as it is related to relationship troubles and self-esteem. Having an erection issue at times is not a cause for concern. However, if you are repeatedly not able to obtain or maintain a healthy penile erection, you must visit your doctor, as it can also be a sign of an underlying medical condition.

Erectile Dysfunction Causes

There are numerous causes of developing erectile dysfunction, which can be broadly classified into two categories- Physical and Psychological. About 80% of the ED cases have a physical cause.

The most common physical causes include diabetes, obesity, cardiovascular diseases, sleep disorders, hypertension, prostate enlargement or prostate cancer treatment, and use of certain medications like antidepressants. The most common psychological causes include anxiety, depression, and stress.

Erectile Dysfunction Treatment

Currently, four oral ED medicines are widely used for treating erectile dysfunction in men. These include Sildenafil citrate, Tadalafil, Vardenafil, and Avanafil. These are administered as oral tablets. These drugs belong to a class of drugs called PDE-5 inhibitors.

  • Sildenafil citrate – Sildenafil citrate was the first oral drug approved by the FDA for the treatment of erectile dysfunction. It was discovered by a group of scientists working at Pfizer, a pharmaceutical company while looking for a treatment of angina. It is sold as the brand name ‘Viagra’. You can observe its effect within 30 to 60 minutes. The action of Sildenafil lasts for about four to five hours on an average. It is sold in three standard doses 25mg, 50mg, and 100mg.
  • Tadalafil – Tadalafil was approved by the FDA for the treatment of erectile dysfunction in 2003. It is the most preferred ED medicine due to its long duration of action of 36 hours. The usual onset of action of Tadalafil is 30 minutes. It is marketed under the trade name Cialis. It is sold in various doses such as 2.5mg, 5mg, 10mg, and 20mg doses.
  • Vardenafil – Vardenafil is available under the brand Levitra. The onset of action and duration of the effect of Vardenafil is 30 minutes and five to seven hours respectively. It is available in 2.5mg, 5mg, 10mg, and 20mg doses.
  • Avanafil – It is sold under the brand names Stendra. The FDA approved it in 2012. It has the fastest onset of action among all ED medicines. Most of the users were able to indulge in sexual activity within 15 minutes. It is sold in 50mg, 100mg, and 200mg doses.

How do these ED medicines work?

ED medicines are potent PDE-5 inhibitors. They are not aphrodisiacs and thus they do improve sexual drive. These medicines produce effective results only in men who are sexually stimulated. When a man is sexually excited, there is a release of nitric oxide by cavernous nerves and endothelial cells. This triggers the synthesis of cyclic guanosine monophosphate (cyclic GMP) by guanylate cyclase.

All the ED medicines inhibit PDE-5 type enzyme, the main enzyme that degrades cyclic GMP in the corpus cavernosum. Inhibition of PDE-5 enzyme increases the levels of cycle GMP inside the penile region, resulting in the dilation of the blood vessels and relaxation of smooth muscles. The dilated blood vessels supply more amount of blood to the penile organ. The outcome is a healthy penile erection.

Take these medicines at least 30 minutes before indulging in sexual activity. Do not take more than one oral tablet in a day. Take these only when you have an urge to indulge in sexual activity. Avoid consuming heavy and fatty meals before taking ED medicines.